Quality of life in Parkinson's disease: The relative importance of the symptoms
Identifieur interne : 002662 ( Main/Exploration ); précédent : 002661; suivant : 002663Quality of life in Parkinson's disease: The relative importance of the symptoms
Auteurs : Shibley Rahman [Royaume-Uni] ; Harry J. Griffin [Royaume-Uni] ; Niall P. Quinn [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-07-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Accidental Falls, Activities of Daily Living, Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Anxiety (etiology), Anxiety (psychology), Cognition Disorders (etiology), Cognition Disorders (psychology), Depression, Depression (etiology), Depression (psychology), Disabled Persons (psychology), Dyskinesia, Drug-Induced (etiology), Dyskinesia, Drug-Induced (psychology), England (epidemiology), Female, Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (psychology), Humans, Male, Middle Aged, Mobility, Nervous system diseases, Pain (etiology), Pain (psychology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Quality of Life, Quality of life, Questionnaires, Severity of Illness Index, Sleep Disorders, Intrinsic (etiology), Sleep Disorders, Intrinsic (psychology), Urinary Incontinence (etiology), Urinary Incontinence (psychology), depression., mobility, quality of life, symptoms.
- MESH :
- chemical , adverse effects : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- geographic , epidemiology : England.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Anxiety, Cognition Disorders, Depression, Dyskinesia, Drug-Induced, Gait Disorders, Neurologic, Pain, Sleep Disorders, Intrinsic, Urinary Incontinence.
- psychology : Anxiety, Cognition Disorders, Depression, Disabled Persons, Dyskinesia, Drug-Induced, Gait Disorders, Neurologic, Pain, Parkinson Disease, Sleep Disorders, Intrinsic, Urinary Incontinence.
- Accidental Falls, Activities of Daily Living, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Quality of Life, Questionnaires, Severity of Illness Index.
Abstract
A body of literature now exists, which demonstrates that idiopathic Parkinson's disease (PD) has a major negative impact on quality of life (QoL), and that depression and cognitive impairment are among the main predictors of poor QoL in this disorder. Relatively little work has been done to assess the differential contribution of the specific symptoms of PD to QoL, which was the aim of this study. One hundred thirty patients with PD completed a booklet of questionnaires, which included the PDQ39 as a disease‐specific measure of QoL, a symptom checklist, a mobility checklist, as well as patient ratings of disease stage and disability. The results indicated that the contribution of physical, medication‐related, and cognitive/psychiatric symptoms to QoL can be significant. Sudden unpredictable on/off states, difficulty in dressing, difficulty in walking, falls, depression, and confusion were PD symptoms, which significantly influenced QoL scores. Among the mobility problems associated with PD, start hesitation, shuffling gait, freezing, festination, propulsion, and difficulty in turning had a significant effect on QoL scores. In addition to depression and anxiety, the major predictors of QoL were shuffling, difficulty turning, falls, difficulty in dressing, fatigue, confusion, autonomic disturbance particularly urinary incontinence, unpredictable on/off fluctuations, and sensory symptoms such as pain. The implications of these results for the medical management of PD are discussed. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21667
Affiliations:
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Le document en format XML
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<term>Activities of Daily Living</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Anxiety (etiology)</term>
<term>Anxiety (psychology)</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognition Disorders (psychology)</term>
<term>Depression</term>
<term>Depression (etiology)</term>
<term>Depression (psychology)</term>
<term>Disabled Persons (psychology)</term>
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<term>Dyskinesia, Drug-Induced (psychology)</term>
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<term>Gait Disorders, Neurologic (psychology)</term>
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<term>Mobility</term>
<term>Nervous system diseases</term>
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<term>Pain (psychology)</term>
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<term>Sleep Disorders, Intrinsic (psychology)</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">A body of literature now exists, which demonstrates that idiopathic Parkinson's disease (PD) has a major negative impact on quality of life (QoL), and that depression and cognitive impairment are among the main predictors of poor QoL in this disorder. Relatively little work has been done to assess the differential contribution of the specific symptoms of PD to QoL, which was the aim of this study. One hundred thirty patients with PD completed a booklet of questionnaires, which included the PDQ39 as a disease‐specific measure of QoL, a symptom checklist, a mobility checklist, as well as patient ratings of disease stage and disability. The results indicated that the contribution of physical, medication‐related, and cognitive/psychiatric symptoms to QoL can be significant. Sudden unpredictable on/off states, difficulty in dressing, difficulty in walking, falls, depression, and confusion were PD symptoms, which significantly influenced QoL scores. Among the mobility problems associated with PD, start hesitation, shuffling gait, freezing, festination, propulsion, and difficulty in turning had a significant effect on QoL scores. In addition to depression and anxiety, the major predictors of QoL were shuffling, difficulty turning, falls, difficulty in dressing, fatigue, confusion, autonomic disturbance particularly urinary incontinence, unpredictable on/off fluctuations, and sensory symptoms such as pain. The implications of these results for the medical management of PD are discussed. © 2007 Movement Disorder Society</div>
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